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All times are CEST (UTC + 2)
| Chelsea – Man Utd. | 2:2 (end) | | | Bournemouth – Southampton | 0:0 (end) | | | Manchester City – Burnley | 5:0 (end) |
| West Ham – Tottenham | 0:1 (end) | | | Wolverhampton – Watford | 0:2 (end) | | | Huddersfield Town – Liverpool | 0:1 (end) |
| Real – Levante | 1:2 (end) | | | Valencia – Leganés | 1:1 (end) | | | Villarreal – Atlético | 1:1 (end) |
| Barcelona – Sevilla | 4:2 (end) |
| Augsburg – RB Leipzig | 0:0 (end) | | | Leverkusen – Hannover | 2:2 (end) | | | Norimberk – Hoffenheim | 1:3 (end) |
| Stuttgart – Dortmund | 0:4 (end) | | | Wolfsburg – Bayern | 1:3 (end) | | | Schalke – Bremen | 0:2 (end) |
| Excelsior – Arnhem | 2:0 (end) | | | Eindhoven – Emmen | 6:0 (end) | | | Heerenveen – Ajax | 0:4 (end) |
| Utrecht – Alkmaar | 2:1 (end) |
| Mouscron – Standard | 0:0 (end) | | | Antwerp – Lokeren | 2:1 (end) | | | Kortrijk – Sint-Truiden | 3:1 (end) |
| Genk – Eupen | 2:1 (end) |
| Hartberg – Rapid | 3:0 (end) | | | Linz – Rheindorf Altach | 1:1 (end) | | | Salzburg – Wacker | 1:1 (end) |
| Orenburg – Jenisej | 0:0 (end) | | | Ural – Samara | 1:1 (end) | | | Ufa – Kazaň | 0:0 (end) |
| Olomouc – Zlín | 1:1 (end) | | | Příbram – Jablonec | 0:6 (end) | | | Ostrava – Karviná | 1:1 (end) |
| Slovácko – Teplice | 0:2 (end) |
| Trnava – Senica | 4:1 (end) | | | Slovan Bratislava – Zlaté Moravce | 3:1 (end) | | | Dunajská Streda – Podbrezová | 3:2 (end) |
| Žilina – Michalovce | 2:2 (end) |
Goals:
3. Schöne, 42. Zijach, 52. Tadić (pen.), 56. Dolberg
Ball possession: 34 % : 66 %.
Shots on target: 4:10. Shots off target: 6:6. Corners: 5:10. Offsides: 3:0. Fouls: 9:12.
Referees:
Attendance:
Cards: 44. Thorsby (HEE), 51. Höegh (HEE) – 71. Neres (AJA)
Penalty missed:
Ball possession: 34 % : 66 %.
Shots on target: 4:10. Shots off target: 6:6. Corners: 5:10. Offsides: 3:0. Fouls: 9:12.
SC Heerenveen:
Hahn – Floranus, Höegh (C), Bulthuis, Pierie – Thorsby, Vlap (63. R. Kongolo), B. Rienstra – Kobajaši (69. van Bergen), S. Lammers (84. van Amersfoort), Zeneli.
Subs: Bednarek, Doornbusch – Hornkamp, R. Kongolo, Mihajlović, Naess, Rojas, van Amersfoort, van Bergen, Woudenberg.
Coach:
Ajax Amsterdam: Onana – Kristensen, de Ligt (C), Wöber, Blind – Schöne, van de Beek, F. de Jong (71. Labyad) – Zijach (57. Neres), Dolberg (57. Huntelaar), Tadić.
Subs: Lamprou – de Wit, Eiting, Huntelaar, Labyad, Mazraoui, Neres, Schuurs.
Coach:
Subs: Bednarek, Doornbusch – Hornkamp, R. Kongolo, Mihajlović, Naess, Rojas, van Amersfoort, van Bergen, Woudenberg.
Coach:
Ajax Amsterdam: Onana – Kristensen, de Ligt (C), Wöber, Blind – Schöne, van de Beek, F. de Jong (71. Labyad) – Zijach (57. Neres), Dolberg (57. Huntelaar), Tadić.
Subs: Lamprou – de Wit, Eiting, Huntelaar, Labyad, Mazraoui, Neres, Schuurs.
Coach:
Referees:
Attendance:
AFC Ajax substitution: Hakím Zijach is replaced by David Neres.